姓  名:洪治

学  院:生命科学院

职  称:教授(博导)

职  务:

邮  箱:zhihong@nju.edu.cn

个人主页:

介  绍:
洪治老师于1996年毕业于辽宁大学化学系,获学士学位。1998年考取东北大学生物工程专业开始植物学研究,2001年获硕士学位。2001年5月入读日本名古屋(Nagoya University)大学,进行水稻油菜素内酯(brassinoteroids)的合成突变研究,2005年3月获博士学位。同年获日本学术振兴会(JSPS)奖学金资助,作为外国人特别研究员继续从事水稻油菜素内酯突变体的分析、鉴定。2006年1月开始到美国密歇根大学(University of Michigan, Ann Arbor)做博士后,研究内质网蛋白折叠系统、Asn-糖基化对油菜素内酯受体突变亚细胞定位的调控。2009年受聘于南京大学生命科学学院。 目前的研究兴趣为1)油菜素内酯受体突变在内质网中滞留的机制;2)蛋白糖基化(N-glycosylation)的发生对植物生长发育的调节机理。发表文章: 1. Z. Hong, H. Jin, A.C. Fitchette, Y. Xia, A.M. Monk, L. Faye and J. Li (2009) Mutations of an alpha1,6 mannosyltransderase inhibit endoplasmic reticulum-assocated degradation of defective brassinosteroid receptors in Arabidopsis. Plant Cell. 21, 3792-3802. 2. H. Jin, Z. Hong, W. Su and J. Li (2009) A plant-specific calreticulin is a key retention factor for a defective brassinosteroid receptor in the endoplasmic reticulum. Proc Natl Acad Sci USA 106, 13612-13617. 3. Z. Hong, H. Jin, T. Tzfira and J. Li (2008) Multiple mechanism-mediated retention of a defective brassinosteroid receptor in the endoplasmic reticulum. (2008) Plant Cell. 20, 3418-3429. 4. A. Nakamura, S. Fujioka, H. Sunohara, N. Kamiya, Z. Hong, Y. Inukai, K. Miura, S. Takatsuto, S. Yoshida, M. Ueguchi-Tanaka, Y. Hasegawa, H. Kitano and M. Matsuoka (2006) The role of OsBRI1 and its homologous genes, OsBRL1 and OsBRL3, in rice. Plant Physiol., 140, 580-590. 5. Z. Hong, M. Ueguchi-Tanaka, S. Fujioka, S. Takatsuto, S. Yoshida, M. Ashikari, H. Kitano and M. Matsuoka (2005) The Rice brassinosteroid-deficient dwarf2 mutant, defective in the rice homolog of Arabidopsis DIMINUTO/DWARF1, is rescued by the endogenously accumulated alternative bioactive brassinosteroid, dolichosterone. Plant Cell, 17, 2243-2254. 6. Z. Hong, M. Ueguchi-Tanaka, and M. Matsuoka (2004) Brassinosteroid and rice architecture. J. Pestic. Sci, 29, 184-188. 7. Z. Hong, M. Ueguchi-Tanaka, K. Umemura, S. Uozu, S. Fujioka, S. Takatsuto, S Yoshida, M. Ashikari, H. Kitano, and M. Matsuoka (2003) A rice brassinosteroid-deficient mutant, ebisu dwarf (d2), is caused by a loss of function of a new member of cytochrome P450. Plant Cell, 15, 2900-2910. 8. Z. Hong, M. Ueguchi-Tanaka, S. shimizu-Sato, Y. Inukai, S. Fujioka, Y. Shimada, S. Takatsuto, M. Agetsuma, S. Yoshida, Y. Watanabe, S. Uozu, H. Kitano, M. Ashikari, M. Matsuoka (2002). Loss-of-function of a rice brassinosteroid biosynthetic enzyme, C-6 oxidase, prevents the organized arrangement and polar elongation of cells in the leaves and stems. The Plant Journal, 32, 495-508.